research
Our research group has broad interests in the areas of drug delivery system (DDS). The lab has been located in a new pharmacy building in Hanyang University, ERICA campus since 2011. With the equipments such as Zetasizer, HPLC system, High pressure homogenizer, Franz cell diffusion system and DSC/TGA system, we are currently studying the following research topics.
Research Interests
- - Lipid-based nanoparticulate system
- - Theranostic nanoparticies for anticancer therapy
- - Bioresponsive drug delivery system for targeted drug delivery
- - Carriers for biopharmaceutical proteins, antibodies, genes and vaccines
1. Drug Delivery System(DDS)
Drug delivery systems (DDS) are capable of controlling the rate of drug delivery, sustaining the duration of therapeutic activity and targeting the drug to the disease tissue leading to better therapeutic effect with minimum side effects.
The principal aim of DDS technology is to ensure that drugs get into the body and reach the area where they are needed. To achieve this goal, DDS technology has been studied to develop novel carriers and formulation or to apply to other administration routes.
The advantage of drug delivery system are the Increased efficacy and therapeutic index of medicines (reduced toxicity of the encapsulated drugs), modulation of pharmacokinetic behavior and tissue distribution, the Increased drug solubility and stability and the targeted delivery to specific tissues/cells.
2. Nano DDS
Our group especially focuses on the nanoparticulate systems (Nano DDS) including liposomes, nonoemulsions, lipid nanoparticles and polymeric micelles.
3. Design and development of Nanocarries
In our group, Nanocarries are designed and developed by following procedures.
4. Application o fNanocarriers
The developed nanocarriers are applied to anticancer therapy and diagnosis. When the nanocarriers containing anticancer drug ae administered, they can be accumulated in tumor tissue by EPR effect and targeting ligand, and can release the incorporated drug via bioresponsive manner.